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Health warnings on tobacco products must now cover at least 65 per cent of the front and back packages, and the tar, nicotine and carbon monoxide labels smokers are used to will be replaced with the messages smoking kills as well as Tobacco smoke contains over 70 substances known to cause cancer

Nicotine is a marker for other toxic components of thirdhand smoke, but is also a concern in itself as nicotine can be changed into the highly toxic and carcinogenic tobacco-specific nitrosamine NNK, as shown by researchers at Lawrence Berkeley National Laboratory

Adding to the complexity, p53 mutations have been reported to occur at different stages of malignant transformation [97]

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